Analytical

Large Molecule Analytical

State-of-the-Art analytical portfolio enables full characterization of biologics covering physicochemical methods and bioassays.

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Potency

Apoptosis
Induction of ADCC (PBMC & reporter gene)
Induction of CDC
Induction of ADCP (reporter gene)
Inhibition of cell proliferation
Target neutralization bioassays
T cells activation (immune checkpoint blockade)
Cytokine release/inhibition assays

Binding to target (Elisa/SPR/FACS)

Soluble target binding
Binding to trans-membrane target
Competition binding
FcyR binding
C1q binding
FcRn binding

Aggregation / Degradation / Charge Variants

SDS-PAGE	CEX-HPLC	cIEF
CE-SDS	cIEF	icIEF
SE-HPLC	DLS

Spectroscopy

UV
CD Near UV
CD Far UV
FT-IR
DSC

Sequence & Identify

Precise Mass Intact
Precise Mass Reduce/Deglycosylated
Disulfide Linkage Analysis
Deamidation
Oxidation
Truncations
Peptide Mapping and Sequencing
N-Terminal Modifications
C-Terminal Modifications

Glycan Analysis

NP-HPLC (2AB/Rapifluor)
HPAEC-PAD
Intact Mass

Purity

Residual DNA
Residual Protein A
Residual Ni2+
HCP

Binding Kinetics (SPR)

Binding kinetics to target