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Analytical

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 Analytical

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Large Molecule Analytical

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State-of-the-Art analytical portfolio enables full characterization of biologics covering physicochemical methods and bioassays.

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Apoptosis
Induction of ADCC (PBMC & reporter gene)
Induction of CDC
Induction of ADCP (reporter gene)
Inhibition of cell proliferation
Target neutralization bioassays
T cells activation (immune checkpoint blockade)
Cytokine release/inhibition assays

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Soluble target binding
Binding to trans-membrane target
Competition binding
FcyR binding
C1q binding
FcRn binding

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SDS-PAGE CEX-HPLC cIEF
CE-SDS cIEF icIEF
SE-HPLC DLS

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UV
CD Near UV
CD Far UV
FT-IR
DSC

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Precise Mass Intact
Precise Mass Reduce/Deglycosylated
Disulfide Linkage Analysis
Deamidation
Oxidation
Truncations
Peptide Mapping and Sequencing
N-Terminal Modifications
C-Terminal Modifications

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NP-HPLC (2AB/Rapifluor)
HPAEC-PAD
Intact Mass

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Residual DNA
Residual Protein A
Residual Ni2+
HCP

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Binding kinetics to target

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Capabilities

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vials

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